ea0066oc6.3 | Oral Communications 6 | BSPED2019
Bendor-Samuel Owen
, Wishlade Tabitha
, Vatish Manu
, Ziegler Anette-Gabriele
, Bonifacio Ezio
, Todd John A
, Snape Matthew
, Group GPPAD Study
Introduction: The successful prevention of type 1 diabetes (T1D) is a major clinical goal. The pathogenesis is multifactorial, with genetic and environmental influences that lead to a break in immune tolerance toward pancreatic beta cells. Through a number of prospective cohort studies, it is now understood that the presence of two or more diabetes-associated autoantibodies is highly predictive of future T1D diagnosis. In addition to the genetic rationale (insulin gene sequenc...